What Is Midodrine Used For

What is midodrine?

ProAmatine is indicated for the handling of symptomatic orthostatic hypotension (OH). Because ProAmatine tin can cause marked meridian of supine blood force per unit area (BP>200 mmHg systolic), it should be used in patients whose lives are considerably dumb despite standard clinical care, including non-pharmacologic handling (such as support stockings), fluid expansion, and lifestyle alterations. The indication is based on ProAmatine's outcome on increases in 1-infinitesimal standing systolic claret pressure, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of ProAmatine, principally improved ability to perform life activities, take not been established. Further clinical trials are underway to verify and describe the clinical benefits of ProAmatine.

*This section republished from FDA prescribing data

What brand names are available for midodrine?

Orvaten, ProAmatine

Is midodrine available every bit a generic drug?

Yes

Do I demand a prescription for midodrine?

Yeah

What are the side furnishings of midodrine?

The nigh common side effects of midodrine handling are tingling, tickling, burning or prickling awareness, supine and sitting hypertension, numbness and itching which mainly affects the scalp area, goose bumps, chills, urinary urge, urinary retention, and urinary frequency.

Rare side effects associated with midodrine treatment are weakness, dry mouth, difficulty sleeping, anxiety, backache, canker sores, confusion, dizziness, dry skin, erythema, facial flushing, gas, upset stomach, heartburn, leg cramps, nausea, tiredness, and vision bug.

What is the dosage for midodrine?

Orthostatic hypotension: The recommended dose is 2.v to 10 mg three times daily during daytime hours while the patient is upright and participating in activities of daily living. The usual dose is 10 mg 3 times daily. A 4-hour interval should be observed shortly before or upon arising in the morning, midday, and late afternoon (no later than six PM). Midodrine should not be given more frequently than every 3 hours. The maximum daily dose is 40 mg. Midodrine should non exist given subsequently the evening meal or less than 4 hours earlier bedtime. Midodrine should only be connected in patients who reply during initial treatment.

SLIDESHOW

Depression Claret Pressure (Hypotension): Symptoms, Signs, Causes See Slideshow

Which drugs or supplements collaborate with midodrine?

Midodrine may cause a decrease in the heart charge per unit. Circumspection should be used when midodrine is given in other medications that may besides reduce the heart rate such every bit cardiac glycosides, tricyclic antidepressants, beta blockers, and other agents.

Medications which accept similar stimulatory effects on alpha-adrenergic receptors may enhance the pressor furnishings of midodrine. Examples of such medications include phenylephrine, pseudoephedrine, ephedrine, phenylpropanolamine, dihydroergotamine, and other agents that cause vasoconstriction.

Blastoff-adrenergic blocking agents such every bit prazosin (Minipress), terazosin (Hytrin), and doxazosin (Cardura) may antagonize or cancel out the effects of midodrine therapy.

Midodrine may compete with drugs such as metformin (Glucophage), cimetidine (Tagamet), ranitidine (Zantac), procainamide (Pronestyl), triamterene (Dyrenium), flecainide (Tambocor), and quinidine for emptying past renal tubular secretion (clearance through the kidneys). Caution should be used if midodrine must be used with any of these agents.

Is midodrine safe to have if I'm significant or breastfeeding?

It is not known if midodrine is excreted in breast milk. Due to the lack of safe data, midodrine should be used cautiously in nursing mothers.

What else should I know virtually midodrine?

What preparations of midodrine are available?

Tablets: 2.5 mg, five mg, 10 mg

How should I go along midodrine stored?

Tablets should be stored at room temperature betwixt 15 C to 30 C (59 F to 86 F).

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Summary

Midodrine (Orvaten, ProAmatine) is a medication prescribed to treat symptomatic orthostatic hyopotension (low blood pressure level upon continuing). Side effects, drug interactions, warnings, precautions, dosage, storage, and pregancy data should exist reviewed prior to taking this medication.

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Related Disease Atmospheric condition

Depression Blood Pressure (Hypotension)

Depression blood pressure, also referred to every bit hypotension, is blood force per unit area that is so low that information technology causes symptoms or signs due to the low menstruation of claret through the arteries and veins. Some of the symptoms of low claret pressure level include light-headedness, dizziness, and fainting if not enough blood is getting to the encephalon. Diseases and medications can as well cause low blood pressure level. When the flow of blood is besides low to deliver enough oxygen and nutrients to vital organs such as the brain, heart, and kidneys; the organs do not function usually and may be permanently damaged.
Orthostatic Hypotension

Orthostatic hypotension symptoms include: LightheadednessWeaknessBlurred vision Syncope or passing out Causes of orthostatic hypotension include: Dehydration, Anemia, Medication Claret loss Depression claret pressure Heat related illnesses Parkinson'south disease Diabetes Treatment of orthostatic hypotension depends on the underlying cause.
POTS (POT Syndrome, Postural Orthostatic Tachycardia Syndrome)

POT syndrome (POTS, postrual orthostatic tachycardia syndrome) is a nervous organisation disorder that causes lightheadedness and fainting when a person stands up. Treatment may include increasing claret volume and regulating circulatory problems that are responsible for the disorder.

Handling & Diagnosis

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References

Medically reviewed past John P. Cunha, Practise, FACOEP; Board Certified Emergency Medicine

REFERENCE:

FDA Prescribing Information.